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KMID : 1036720160490050288
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Journal of Nutrition and Health
2016 Volume.49 No. 5 p.288 ~ p.294
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Rhamnazin inhibits LPS-induced inflammation and ROS/RNS in raw macrophages
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Kim You-Jung
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Abstract
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Purpose: The aim of this work was to investigate the beneficial effects of rhamnazin against inflammation, reactive
oxygen species (ROS)/reactive nitrogen species (RNS), and anti-oxidative activity in murine macrophage RAW264.7
cells.
Methods: To examine the beneficial properties of rhamnazin on inflammation, ROS/ RNS, and anti-oxidative activity
in the murine macrophage RAW264.7 cell model, several key markers, including COX and 5-LO activities, NO?, ONOO-,
total reactive species formation, lipid peroxidation, ?O2 levels, and catalase activity were estimated.
Results: Results show that rhamnazin was protective against LPS-induced cytotoxicity in macrophage cells. The underlying action of rhamnazin might be through modulation of ROS/RNS and anti-oxidative activity through regulation of total reactive species production, lipid peroxidation, catalase activity, and ?O2, NO?, and ONOO? levels. In addition, hamnazin down-regulated the activities of pro-inflammatory COX and 5-LO.
Conclusion: The plausible action by which rhamnazin renders its protective effects in macrophage cells is likely due to its capability to regulate LPS-induced inflammation, ROS/ RNS, and anti-oxidative activity.
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KEYWORD
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rhamnazin, inflammation, reactive oxygen species, reactive nitrogen species, 5-lipoxygenase
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